The ACAB project
ACAB (Attributable CAncer Burden in Tuscany: smoking, environmental and occupational risk factors and evaluation of prevention strategies) is a three-year scientific project funded by the Tuscany Region as part of the 2018 Health Research Call.
The project is coordinated by the Oncologic Network, Prevention and Research Institute (ISPRO) with the participation of the Department of Statistics, Computer Science, Applications of the University of Florence and the Azienda USL Toscana Centro. The Regional Health Agency (ARS) of Tuscany, the IRCCS Materno Infantile Burlo Garofolo of Trieste and the LaMMA Consortium collaborate with ACAB as external partners.
The main aim of ACAB is to produce an updated estimate for Tuscany of deaths and years of life lived with disabilities (DALY) from cancer caused by smoking, air pollution and occupational exposure to carcinogens. ACAB will quantify the burden of oncological disease which, in the recent years, which could have been avoided by reducing or eliminating harmful exposures.
It will also evaluate the future health benefit for the population deriving from strengthening existent tobacco control policies or implementing new ones, reducing emissions of airborne fine particles and gaseous pollutants and improving workplace healthiness.
Research team

Giulia
Carreras
Istituto per lo Studio, la Rete e la Prevenzione Oncologica (ISPRO)


Michela
Baccini
Dipartimento di Statistica, Informatica, Applicazioni (DISIA), Università di Firenze


Miriam
Levi
Dipartimento di Prevenzione, Azienda USL Toscana Centro (AUSL TC)

Partners

Osservatorio di Epidemiologia
Francesco Profili
Fabio Voller

IRCCS materno infantile Burlo Garofolo
Lorenzo Monasta

Consorzio LaMMA
Divisione Fisica dell’Atmosfera
Qualità dell’aria
Timeline of project developements
Literature review
Collection of epidemiological data and of data on exposure to smoking, air pollution and to the main occupational carcinogens
Development of methods for DALYs estimation
Estimation of DALYs for the leading diseases and for cancers
Exposure assessment
Definition / estimation of dose-response curves
Development of a compartmental model for the dynamics of smoking
Estimation of the burden of disease from cancer due to smoking, to air pollution and to the main occupational carcinogens
Formulation of counterfactual scenarios for smoking habits and for exposure to air pollution and occupational carcinogens and health impact assessment through the compartmental.